"Overall, the book is successful in explaining complicated pharmacokinetics concepts in a manner that is easy to understand and can be quickly referenced."
—Melissa Ranieri, PharmD
Temple University School of Pharmacy

The Handbook of Basic Pharmacokinetics . . . Including Clinical Applications is a great resource on the most relevant scientific information for students, researchers, and practitioners. Readers will find the book current, accurate, comprehensive, and clinically useful. A chapter titled "Pharmacogenetics and Pharmacogenomics" addresses the influence of genetic constitution on the enzymes and transporters that affect drug disposition and action.

Table of Contents
• Definitions and Glossary
• The LADMER System: Drug Liberation, Absorption, Distribution, Metabolism, Elimination, and Response
• Organs, Tissues, Cells, and Organelles
• Cell Membranes — Structure, Functions, and Properties
• Drug Receptor Interactions
• Absorption/Transport Mechanisms
• pKa and Degree of Ionization
• Lipid/Water Partition Coefficient
• Physico-Chemical Factors Altering Biological Performance of Drugs
• Biopharmaceutical Data of the Gastrointestinal Tract
• Fluid Compartments and Circulatory System (Blood and Lymph)
• Binding of Drugs to Biological Material
• Drug Biotransformation
• Compartment Models
• Determination of Rate Constants
• Volume of Distribution and Distribution Coefficient
• Excretion and Clearance of Drugs
• Urinary and Biliary Recycling
• Cumulative Urinary Excretion
• Area Under the Blood Level–Time Curve
• Pharmacokinetics of Single Dose Administration
• Pharmacokinetics of Multiple Dosing
• Compartment Model Independent Analysis
• Pediatric Pharmacokinetics
• Drug Dosage in Elderly Patients
• Drug Dosage in Obese Patients
• Drug Disposition in Pregnancy
• Dosage Regimen Design
• Drug Monitoring and Dose Adjustment
• Physiological and Pathological Factors Influencing Drug Response
• First Dose Size in Man
• Forensic Pharmacokinetics
• Nonlinear Pharmacokinetics
• Curve Fitting
• Correlation of Clinical Response with Drug Disposition
• Bioavailability and Bioequivalence
• Body Surface Area
• Extracorporeal Methods of Drug Removal
• Pharmacogenetics and Pharmacogenomics