Job-related stress and burnout are at all-time highs across professions. In the 2023 American Psychological Association Work in America Survey, 77% of workers reported experiencing work-related stress in the last month, and 57% reported experiencing negative impacts because of work-related stress. This Pharmacy Today CPE will illustrate the differences between, and causes of, chronic stress and burnout and to provide actionable, evidence-based recommendations for mitigating the effects of chronic stress.